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The Synthesis of N ‐Glycosyl‐ N′ ‐Pyrazolylmethylene Aminothioureas under a 4Å Molecular Sieve
Author(s) -
Zhao YanWu,
Cao LingHua
Publication year - 2008
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200800056
Subject(s) - chemistry , glycosyl , molecular sieve , yield (engineering) , reagent , fluorescence , sugar , derivative (finance) , organic chemistry , catalysis , materials science , physics , quantum mechanics , economics , financial economics , metallurgy
A series of novel N ‐glycosyl‐ N′ ‐pyrazolylmethylene aminothioureas ( 4a‐4e, 5a‐5e ) were synthesized from N ‐glycosyl‐ N′ ‐aminothioureas ( 2a‐2d ) and 4‐formylpyrazole ( 3a‐3e ). Activated 4Å molecular sieves were adopted for dehydrated reagent to improve the reaction rate and yield. The structures of the new compounds were identified on the basis of IR, 1 H NMR and MS spectra. Simultaneously, the compounds were detected by fluorescence spectrophotometer and had preferable fluorescence activity, so they can be selected as a kind of novel fluorescence labeled derivative of sugar.