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Kinetic‐Spectrophotometric Determination of Metronidazole Benzoate in Surfactant Medium
Author(s) -
Farhadi Khalil,
Bahar Shahriyar
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700214
Subject(s) - chemistry , chromatography , pulmonary surfactant , calibration curve , kinetic energy , metronidazole , sodium benzoate , sodium , analytical chemistry (journal) , detection limit , antibiotics , organic chemistry , biochemistry , physics , food science , quantum mechanics
A kinetic method for the accurate and sensitive determination of metronidazole benzoate (MB) has been described. The method is based on the oxidation of MB with KMnO 4 in alkaline medium in the presence of sodium dodecyl sulphate (SDS). At a fixed time of 10 min, the formed magnate ion is spectrophotometrically measured at 610 nm. The determination of MB by the fixed‐concentration and rate constant method is feasible with the calibration equation obtained, but the fixed‐time method proves to be more applicable. The proposed method was successfully used for the quantitative determination of MB in suspended oral syrup after the separation of MB with a simple separation method. Beer's law was obeyed from 0.55 mgL −1 to 33 mgL −1 and the RSD% value for syrup was 3.44. The results obtained agreed with those obtained by the BP method.