Premium
FTIR, 1 H NMR, ESR, TGA and DTA Analysis of Trithiocarbonates of Captopril and 6‐Mercaptopurine as Their Palladium(II) Chloride Complexes
Author(s) -
Sharma Mukul,
Koty Afraim,
Srivastava Mamta,
Srivastava Ashutosh
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700202
Subject(s) - chemistry , palladium , captopril , reagent , proton nmr , fourier transform infrared spectroscopy , nuclear chemistry , analytical chemistry (journal) , chromatography , stereochemistry , organic chemistry , catalysis , medicine , physics , quantum mechanics , blood pressure , radiology
Abstract A simple and sensitive spectrophotometric method has been developed for the determination of the antihypertensive drug captopril and anticancer drug 6‐mercaptopurine, in their trithiocarbonate (TTC) form by using Pd(II) chloride as a coloring reagent. Captopril TTC forms a stable dark yellow colored complex with λ max 383 nm, molar absorption coefficient 1.35 × 10 5 l/mole/cm and a Beer's law range from 0.084‐1.26 ppm. 6‐Mercaptopurine TTC forms a stable deep yellow colored complex with λ max 345 nm, molar absorption coefficient 6.9 × 10 5 l/mole/cm and a Beer's law range from 0.0319 ppm to 3.519 ppm. The M: L ratio of palladium: TTC complexes were confirmed by Job's method of continuous variance and mole ratio method and was found to be 1:1 for both captopril TTC as well as 6‐mercaptopurine TTC. In addition, on the basis of, FTIR, 1 H NMR, ESR and thermal analysis data a plausible structure of mononuclear Pd(II) complex of Captopril TTC and 6‐mercaptopurine TTC has been reported.