One‐Pot Synthesis of Pyrido[2,3‐ d ]Pyrimidine‐2‐Thiones and a Study of Their Reactivity Towards Some Reagents | Zendy

ElGazzar A. B. A. | Zendy; Hafez H. N. | Zendy; Yakout E. M. A. | Zendy

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One‐Pot Synthesis of Pyrido[2,3‐ d ]Pyrimidine‐2‐Thiones and a Study of Their Reactivity Towards Some Reagents

Author(s) -

ElGazzar A. B. A.,

Hafez H. N.,

Yakout E. M. A.

Publication year - 2007

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200700184

Subject(s) - chemistry , malononitrile , reagent , pyrimidine , aldehyde , formamide , reactivity (psychology) , organic chemistry , combinatorial chemistry , medicinal chemistry , stereochemistry , catalysis , medicine , alternative medicine , pathology

A series of pyrido[2,3‐ d ]pyrimidine‐2‐thione derivatives ( 5a‐c ) were synthesized by the one‐pot reaction of the appropriate aldehyde, malononitrile and 6‐aminothiouracil ( 1 ) in dimethyl‐formamide. The same compounds were also synthesized by the reaction of arylidine malononitrile ( 4 ) with 6‐aminothiouracil ( 1 ). Moreover, the chemical behaviour of the produced pyrimidines towards different reagents was studied.

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