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Synthesis and Biological Activity of Mercaptobenzoxazole Based Thiazolidinones and Their Arylidenes
Author(s) -
Kohli P.,
Srivastava S. D.,
Srivastava S. K.
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700144
Subject(s) - chemistry , aspergillus niger , fusarium oxysporum , candida albicans , antimicrobial , bacillus subtilis , agar dilution , pathogenic bacteria , aryl , serial dilution , potency , escherichia coli , bacteria , microbiology and biotechnology , organic chemistry , minimum inhibitory concentration , food science , biochemistry , in vitro , botany , medicine , genetics , alkyl , alternative medicine , pathology , gene , biology
Arylidenes of thiazolidines with mercaptobenzoxazole, namely[(aryl‐4‐oxo‐1,3‐thiazolidin)‐hydrazinoacetyl‐mercaptobenxazole]; (5‐arylidene)‐2‐aryl‐4‐oxo‐1,3‐thiazoliden hydrazinoacetyl‐mercaptobenxazole were synthesized. Their chemical structures have been confirmed by 1 H NMR, IR, mass spectra and also by microanalytical data. Antimicrobial evaluation was done by agar dilution method against three pathogenic bacteria viz. Bacillus subtilis , Escherichia coli and Klebsiella pneumoniae and three pathogenic fungi viz. Aspergillus niger , Candida albicans and Fusarium oxysporum . Among new derivatives evaluated, the chloro derivatives exhibited higher potency as compared to the standard drugs streptomycin (for bacteria) and griseofulvin (for fungi) against the tested organisms.