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Liquid‐Phase Synthesis of 2‐Methyl‐2‐Aryloxypropanoic Acid Derivatives from Polyethylene Glycol) Supported 2‐Bromo‐2‐Methylpropanoate
Author(s) -
Huang Bin,
Huang PeiGang,
Sheng ShouRi,
Wang QiuYing,
Guo Lei,
Jiang ShaoHua
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700082
Subject(s) - chemistry , polyethylene glycol , peg ratio , cleavage (geology) , catalysis , organic chemistry , liquid phase , peg 400 , polymer chemistry , nuclear chemistry , medicinal chemistry , physics , geotechnical engineering , finance , fracture (geology) , engineering , economics , thermodynamics
An efficient liquid‐phase synthesis of 2‐methyl‐2‐aryloxypropanoic acid derivatives with good yields and high purity on soluble polyethylene glycol (PEG) has been developed by treatment of PEG‐bound 2‐bromo‐2‐methylpropanoate with phenoxides in the presence of a catalytic amount of NBu 4 I and KI, and subsequent cleavage from the PEG.