Synthesis of 5‐Radioiodoarabinosyl Uridine Analog for Probing the HSV‐1 Thymidine Kinase Gene | Zendy

Lin KunI | Zendy; Chiang LiWu | Zendy; Wu ChienHung | Zendy; Chen ShaoWei | Zendy; Yu ChungShan | Zendy

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Synthesis of 5‐Radioiodoarabinosyl Uridine Analog for Probing the HSV‐1 Thymidine Kinase Gene

Author(s) -

Lin KunI,

Chiang LiWu,

Wu ChienHung,

Chen ShaoWei,

Yu ChungShan

Publication year - 2007

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200700080

Subject(s) - thymidine kinase , chemistry , uridine , thymidine , herpes simplex virus , substrate (aquarium) , kinase , gene , positron emission tomography , microbiology and biotechnology , biochemistry , dna , virus , rna , virology , nuclear medicine , biology , medicine , oceanography , geology

Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5‐[ 125 I] iodoarabinosyl uridine starting from commercially available uridine is reported herein.

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