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Synthesis of 5‐Radioiodoarabinosyl Uridine Analog for Probing the HSV‐1 Thymidine Kinase Gene
Author(s) -
Lin KunI,
Chiang LiWu,
Wu ChienHung,
Chen ShaoWei,
Yu ChungShan
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700080
Subject(s) - thymidine kinase , chemistry , uridine , thymidine , herpes simplex virus , substrate (aquarium) , kinase , gene , positron emission tomography , microbiology and biotechnology , biochemistry , dna , virus , rna , virology , nuclear medicine , biology , medicine , oceanography , geology
Tumor cells transduced with herpes simplex virus thymidine kinase gene have been intensively applied to the field of positron emission tomography via imaging of its substrate. As a pilot synthesis approach, a facile preparation of 5‐[ 125 I] iodoarabinosyl uridine starting from commercially available uridine is reported herein.