Sodium Tetrafluoroborate as a New and Highly Efficient Catalyst for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐Ones and Thiones | Zendy

Bandgar B. P. | Zendy; Kamble V. T. | Zendy; Bavikar S. N. | Zendy; Dhavane Abasaheb | Zendy

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Sodium Tetrafluoroborate as a New and Highly Efficient Catalyst for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐Ones and Thiones

Author(s) -

Bandgar B. P.,

Kamble V. T.,

Bavikar S. N.,

Dhavane Abasaheb

Publication year - 2007

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200700038

Subject(s) - chemistry , thiourea , aldehyde , tetrafluoroborate , catalysis , condensation , urea , organic chemistry , sodium , condensation reaction , medicinal chemistry , ionic liquid , physics , thermodynamics

Sodium tetrafluoroborate (NaBF 4 ) is found to catalyze the three component condensation of an aldehyde, 1,3‐dicarbonyl compound and urea or thiourea to afford the corresponding 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones in high yields. This method is very useful for the synthesis of a wide range of 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones from aromatic, heterocyclic, α,β‐unsaturated aldehydes and aliphatic aldehydes.

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