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Sodium Tetrafluoroborate as a New and Highly Efficient Catalyst for One‐Pot Synthesis of 3,4‐Dihydropyrimidin‐2(1 H )‐Ones and Thiones
Author(s) -
Bandgar B. P.,
Kamble V. T.,
Bavikar S. N.,
Dhavane Abasaheb
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700038
Subject(s) - chemistry , thiourea , aldehyde , tetrafluoroborate , catalysis , condensation , urea , organic chemistry , sodium , condensation reaction , medicinal chemistry , ionic liquid , physics , thermodynamics
Abstract Sodium tetrafluoroborate (NaBF 4 ) is found to catalyze the three component condensation of an aldehyde, 1,3‐dicarbonyl compound and urea or thiourea to afford the corresponding 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones in high yields. This method is very useful for the synthesis of a wide range of 3,4‐dihydropyrimidin‐2(1 H )‐ones and thiones from aromatic, heterocyclic, α,β‐unsaturated aldehydes and aliphatic aldehydes.