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Spectrophotometric Determination of Ondansetron Hydrochloride in Pharmaceutical Bulk and Dosage Forms
Author(s) -
Raza Asad,
Ijaz Abdul Subhan,
Rasheed Uzma
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700033
Subject(s) - chemistry , molar absorptivity , dosage form , berberine hydrochloride , chromatography , ondansetron , chloranil , organic chemistry , high performance liquid chromatography , medicine , physics , optics , nausea
A rapid, simple and accurate spectrophotometric method is developed for the determination of ondansetron hydrochloride in pure and tablet formulations. The method depends on the charge‐transfer complexation between ondansetron base as n‐electron donor with chloranil as π‐acceptor to give a colored complex, which absorbs maximally at 470 nm. Beer's law is obeyed in the concentration ranges 70–980 μg mL −1 with molar absorptivity of 4.47 × 10 2 L mole −1 cm −1 . The proposed method is precise, accurate and specific for the quantitative determination of drug in bulk and tablet formulations.