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One‐Pot Synthesis of 6,7‐Fused Steroidal Thiazoles in Cholestane Series
Author(s) -
Mushfiq M.,
Mahboob A.
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700032
Subject(s) - chemistry , thiourea , cholestane , thiazole , iodine , organic chemistry , combinatorial chemistry
A convenient one‐pot synthesis of 2′‐amino‐ and 2′‐ N ‐phenylamino‐5α‐cholest‐6‐eno[6,7‐d]thiazole derivatives 4 ‐ 9 are reported. The synthesis involves the reaction of cholestan‐6‐ones 1 ‐ 3 with thiourea or phenylthiourea and iodine. The products have been characterized on the basis of IR, 1 H‐NMR and Mass, which find support in two cases from comparison with authentic samples.