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Electrochemical Behavior and Determination of Hyoscine‐N‐Butylbromide from Pharmaceutical Preparations
Author(s) -
Farhadi Khalil,
Karimpour Ahmad
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700026
Subject(s) - chemistry , coulometry , acetonitrile , perchlorate , sodium perchlorate , electrochemistry , cyclic voltammetry , platinum , aqueous solution , bromide , differential pulse voltammetry , electrode , voltammetry , inorganic chemistry , analytical chemistry (journal) , chromatography , ion , organic chemistry , catalysis
The electrooxidation of hyoscine N‐butylbromide (HBB) was investigated by rotating disk electrode voltammetry, cyclic voltammetry and controlled potential coulometry in 0.1 M HNO 3 and in 0.1 M tetrabutylammonium perchlorate (TBAP) solutions of acetonitrile at a platinum (Pt) electrode. Based on the results obtained, it is suggested that a bromide ion of HBB was oxidized in one reversible step in aqueous solutions and in two reversible steps in acetonitrile. A differential pulse voltammetric (DPV) method at a Pt electrode was developed for the determination of HBB in the concentration range of 1.0 × 10 −6 ‐1.0 × 10 −3 M. The procedure was applied to the determination of HBB in its formulations as well as its recovery from blood serum and urine samples.