Synthesis and Anti Tuberculostatic Activity of Novel 1,3,4‐Oxadiazole Derivatives | Zendy

Yar M. Shahar | Zendy; Siddiqui A. Ahmad | Zendy; Ashraf Ali M. | Zendy

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Synthesis and Anti Tuberculostatic Activity of Novel 1,3,4‐Oxadiazole Derivatives

Author(s) -

Yar M. Shahar,

Siddiqui A. Ahmad,

Ashraf Ali M.

Publication year - 2007

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200700002

Subject(s) - antimycobacterial , oxadiazole , chemistry , in vitro , mycobacterium tuberculosis , combinatorial chemistry , strain (injury) , stereochemistry , tuberculosis , organic chemistry , biochemistry , medicine , pathology

A series of novel 2,5‐disubstituted 1,3,4‐oxadiazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis H 37 Rv. The result of the antimycobacterial activity tests revealed that 2‐(2‐naphthyloxymethyl)‐5‐phenoxymethyl‐1,3,4‐oxadiazole ( IVd ) exhibited > 90% inhibition at MIC ˜6.25.

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