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Synthesis and Anti Tuberculostatic Activity of Novel 1,3,4‐Oxadiazole Derivatives
Author(s) -
Yar M. Shahar,
Siddiqui A. Ahmad,
Ashraf Ali M.
Publication year - 2007
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200700002
Subject(s) - antimycobacterial , oxadiazole , chemistry , in vitro , mycobacterium tuberculosis , combinatorial chemistry , strain (injury) , stereochemistry , tuberculosis , organic chemistry , biochemistry , medicine , pathology
Abstract A series of novel 2,5‐disubstituted 1,3,4‐oxadiazole derivatives were synthesized and tested for their in vitro antimycobacterial activity. Some compounds showed interesting activity against a strain of Mycobacterium tuberculosis H 37 Rv. The result of the antimycobacterial activity tests revealed that 2‐(2‐naphthyloxymethyl)‐5‐phenoxymethyl‐1,3,4‐oxadiazole ( IVd ) exhibited > 90% inhibition at MIC ˜6.25.