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Indirect Determination of Captopril with Sodium Nitrate and Thiocyanate by Floatation Separation of Copper
Author(s) -
Wang ChunFeng,
Guan Xia,
Li QuanMin,
Liu GuoGuang
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600149
Subject(s) - captopril , chemistry , thiocyanate , copper , sodium nitrate , yield (engineering) , chromatography , sodium thiocyanate , inorganic chemistry , metallurgy , organic chemistry , medicine , materials science , blood pressure
A new method for indirect determination of captopril (CPT) with NaNO 3 and NH 4 SCN by floatation and separation of copper has been studied. In the weak acid, a small amount of Cu(II) can be reduced to Cu(I) by CPT, then Cu(I) reacted with the SCN, which can float on the surface of the liquid phase with NaNO 3 . A good linear relationship is observed between the floatation yield (E%) of Cu(II) and the amount of captopril. The linear range is 2˜32 mg/L. On the ground, captopril can be indirectly determined by determining E(%) of Cu(II). The method is simple, rapid, reliable and has good selectivity. The developed method can be applied to indirect determination of captopril with satisfactory results.