Premium
New Triheterocyclic Ring System. Synthesis of Functionalized Pyrazolo[3,4‐d]Pyrimido[1,2‐b][1,2,4,5]Tetrazine Derivatives
Author(s) -
Mosselhi Mosselhi A. N.,
Hussein Ahmad M.,
Shawali Ahmad Sami
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600123
Subject(s) - chemistry , tetrazine , regioselectivity , ring (chemistry) , halide , derivative (finance) , medicinal chemistry , stereochemistry , combinatorial chemistry , organic chemistry , catalysis , financial economics , economics
New functionalized pyrazolo[3,4‐d]pyrimido[1,2‐b][1,2,4,5]tetrazine derivatives 6a‐q were synthesized via reaction of the hydrazonoyl halides 1a‐q with 5‐amino‐1‐phenyl‐6‐thioxo‐pyrazolo[3,4‐d]pyrimidin‐4‐one 2 and its 2‐methylthio derivative 3 . The mechanism and the regioselectivity of the studied reactions have been discussed.