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A Convenient Access to Functionalized Pyrazole, Pyrazolyl‐Azole, and Pyrazolo[3,4‐d]Pyridazine Derivatives
Author(s) -
Dawood Kamal M.,
Farag Ahmad M.,
AbdelAziz Hatem A.
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600116
Subject(s) - chemistry , pyrazole , pyridazine , phenylisocyanate , azole , hydrazine (antidepressant) , medicinal chemistry , organic chemistry , antifungal , chromatography , medicine , dermatology
3‐(2‐Furyl)‐3‐oxopropanitrile reacts with keto and ester‐hydrazonyl chlorides to afford the corresponding acetyl‐ and ester‐pyrazole derivatives. The latter pyrazoles reacted with hydrazine and gave either the pyrazolo[3,4‐d]pyridazines or pyrazolylhydrazides. Treatment of the latter hydrazides with phenylisothiocyanate and with phenylisocyanate resulted in the formation of the pyrazolylthiadiazole and pyrazolyloxadiazole derivatives, respectively.