Premium
Total Solubility Determination of Mixtures Containing Ampicillin Anhydrate and Ampicillin Trihydrate
Author(s) -
Liu ChenLun,
Chang TianChan,
Wu ShuMin,
Chiang HueyJenn
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600112
Subject(s) - ampicillin , chemistry , solubility , dissolution , chromatography , nuclear chemistry , antibiotics , organic chemistry , biochemistry
The dissolved concentrations of ampicillin anhydrate, ampicillin trihydrate, and their mixtures were experimentally determined. For 100% ampicillin anhydrate and 100% ampicillin trihydrate cases, the dissolved concentration (mg/mL) was equal to the total amount of 100% ampicillin anhydrate and 100% ampicillin trihydrate in 1 mL solution up to the solubility (10.8 mg/mL) of 100% ampicillin anhydrate and the solubility (5.4 mg/mL) of 100% ampicillin trihydrate. For an ampicillin anhydrate to ampicillin trihydrate mixture ratio of 75:25, the relationship between the dissolved concentration and the total amount of the mixture in 1 mL solution was the same as the 100% ampicillin anhydrate case. As for the ampicillin anhydrate to ampicillin trihydrate mixture ratios of 50:50 and 25:75, the total solubility of 10.8 mg/mL could be reached at greater amounts of the mixtures. A model of diffusion‐controlled dissolution rate mechanism with two experimental solubilities, 10.8 mg/mL for ampicillin anhydrate and 5.4 mg/mL for ampicillin trihydrate, was used to successfully interpret the solubility data.