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Ritter Reaction of 1‐Aryl‐1‐Fluoro‐2‐Haloethanes
Author(s) -
Ho TseLok,
Chein RongJie
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600054
Subject(s) - chemistry , ritter reaction , aryl , inert , medicinal chemistry , inert gas , organic chemistry , catalysis , alkyl
Fluorinated phenethyl bromides 1,2 , and 3 , prove to be totally inert under Ritter reaction conditions in the presence of either SnCl 4 or AgNO 3 , due to the strong deactivation by the gem ‐difluoro unit. Subjecting 2‐bromo‐1‐fluoro‐1‐phenylethane to SnCl 4 in MeCN at elevated temperatures led to formation of 2‐methyl‐4‐phenyl‐4,5‐dihydrooxazole.