Premium
Ritter Reaction of 1‐Aryl‐1‐Fluoro‐2‐Haloethanes
Author(s) -
Ho TseLok,
Chein RongJie
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600054
Subject(s) - chemistry , ritter reaction , aryl , inert , medicinal chemistry , inert gas , organic chemistry , catalysis , alkyl
Fluorinated phenethyl bromides 1,2 , and 3 , prove to be totally inert under Ritter reaction conditions in the presence of either SnCl 4 or AgNO 3 , due to the strong deactivation by the gem ‐difluoro unit. Subjecting 2‐bromo‐1‐fluoro‐1‐phenylethane to SnCl 4 in MeCN at elevated temperatures led to formation of 2‐methyl‐4‐phenyl‐4,5‐dihydrooxazole.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom