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An Efficient and High‐Yield One‐Pot Synthesis of Bis(oxazoline)s
Author(s) -
Hui XinPing,
Huang JenI,
Chiou ShianJie,
Gau HanMou
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600053
Subject(s) - chemistry , oxazoline , yield (engineering) , chloride , reaction conditions , combinatorial chemistry , organic chemistry , medicinal chemistry , catalysis , materials science , metallurgy
An efficient and mild one‐pot synthesis of bis(oxazoline) (BOX) ligands is developed from reactions of dicarboxy dichlorides with β‐amino alcohols in the presence of 11.0 equiv. NEt 3 followed by the addition of 3.6 equiv. methanesulfonyl chloride (MsCl). Nine different BOX ligands were prepared in excellent yields of ≥ 80%. Advantages of this improved synthesis are mild reaction conditions, short total reaction time of 9 h, and high isolated yields.