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The First Total Synthesis of the Diastereoisomers A and B of Tuxpanolide from Perymenium hintonii
Author(s) -
Wang JinXin,
Zhang ChaoXin,
Li Ying,
You QiDong
Publication year - 2006
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200600044
Subject(s) - chemistry , diastereomer , total synthesis , aldol reaction , natural product , dehydration , optically active , stereochemistry , organic chemistry , catalysis , biochemistry
Abstract The first total synthesis of the diastereoisomers A and B of the natural product Tuxpanolide have been achieved through the stereo‐controlled construction of optically active β‐hydroxyl‐γ‐butyrolactones, the aldol coupling, dehydration and deprotection reaction with the p ‐TsOH as the key steps.