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Triterpene Acids from the Leaves of Planchonella Duclitan (Blanco) Bakhuizan
Author(s) -
Lee TzongHuei,
Juang ShinHun,
Hsu FengLin,
Wu ChengYi
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500184
Subject(s) - chemistry , ursolic acid , triterpene , cytotoxicity , terpene , human breast , ic50 , stereochemistry , traditional medicine , biochemistry , in vitro , chromatography , cancer , cancer cell , medicine , alternative medicine , pathology
From the methanolic extract of the leaves of Planchonella duclitan , 2α,3α,19α,23‐tetrahydroxy‐13,27‐cyclours‐11‐en‐28‐oic acid (1), myrianthic acid (2), 2‐hydroxyursolic acid (3), ursolic acid (4), pomolic acid (5), rotundic acid (6), and jacoumaric acid (7) were isolated, and their structures were elucidated on the basis of their spectroscopic analysis. Among them, compound 1 was a new cyclopropyl ursane‐type triterpene acid. Additionally, compounds 4 and 7 showed significant cytotoxicity toward human colorectal carcinoma cell line HT29 and human breast carcinoma cell line MCF‐7 with IC 50 values ranging from 5.8 ± 1.4 to 6.5 ± 1.9 μM.