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Utility of β‐(4‐Chlorobenzoyl)acrylic Acid in Heterocyclic Synthesis
Author(s) -
Eissa A. M. F.
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500173
Subject(s) - chemistry , isoxazole , indazole , michael reaction , nucleophile , methylene , diazepine , reactivity (psychology) , acrylic acid , adduct , quinazoline , organic chemistry , ring (chemistry) , catalysis , medicine , polymer , alternative medicine , monomer , pathology
β‐(4‐Chlorobenzoyl)acrylic acid (1) proved to be a convenient precursor for the synthesis of a variety of heterocyclic systems through the reaction with compounds containing active methylene groups under Michael reaction conditions. Also, the reactivity of Michael adduct towards nitrogen nucleophiles was investigated to afford diazepine, indazole, isoxazole and quinazoline derivatives. Some of the synthesized compounds were screened for their biological activity.