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The Study of Electrochemical Characteristics of Methotrexate
Author(s) -
Ye BaoXian,
Qu Song,
Wang Fei,
Li Lin
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500159
Subject(s) - chemistry , electrochemistry , electrode , dropping mercury electrode , voltammetry , cyclic voltammetry , redox , hanging mercury drop electrode , differential pulse voltammetry , detection limit , analytical chemistry (journal) , kinetic energy , buffer solution , inorganic chemistry , chromatography , physics , quantum mechanics
In this paper, the electrochemical characteristics of methotrexate are studied by using different electrochemical methods at the mercury drop electrode. In Britton‐Robinson buffer solution (pH 9.20), a pair of redox peaks of methotrexate controlled by adsorption is obtained by cyclic voltammetry. The differential pulse voltammetry peak currents have a linear relationship with methotrexate concentrations in the range of 1.0 × 10 −;5 mol/L ∼ 1.0 × 10 −;8 mol/L with a detection limit of 2.0 × 10 −;9 mol/L, which has been used in real sample analysis with satisfactory result. Moreover, the electrode reaction mechanism of the system was studied and the kinetic parameters were obtained too. The electrode reduction of MTX is a quasi‐reversible process with two electrons and two protons.