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Synthesis and Biological Activities of 7‐Arylazo‐7 H ‐pyrazolo[5,1‐c][1,2,4] Triazol‐6(5 H )‐Ones and 7‐Arylhydrazono‐7 H ‐[1,2,4]triazolo[3,4‐b] [1,3,4]thiadiazines
Author(s) -
Abdallah M. A.,
Riyadh S. M.,
Abbas I. M.,
Gomha S. M.
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500137
Subject(s) - chemistry , halide , medicinal chemistry , aryl , triazole , stereochemistry , combinatorial chemistry , organic chemistry , alkyl
Two series of 7‐arylazo‐7 H ‐3‐(2‐methyl‐1 H ‐indol‐3‐yl)pyrazolo[5,1‐c][1,2,4]triazol‐6(5 H )‐ones 4 and 7‐arylhydrazono‐7 H ‐3‐(2‐methyl‐1 H ‐indol‐3‐yl)‐[1,2,4]triazolo[3,4‐b][1,3,4]thiadiazines 7 were prepared via reactions of 4‐amino‐3‐mercapto‐5‐(2‐methyl‐1 H ‐indol‐3‐yl)‐1,2,4‐triazole 1 with ethyl arylhydrazono‐chloroacetate 2 and N‐aryl‐2‐oxoalkanehydrazonoyl halides 5 , respectively. A possible mechanism is proposed to account for the formation of the products. The biological activity of some of these products was also evaluated.