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Complexation Equilibria of Zn(II), Pb(II) and Cd(II) with Reduced Glutathione (GSH) and Biologically Important Zwitterionic Buffers
Author(s) -
Anwar Zeinab Mohamed
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500121
Subject(s) - chemistry , potentiometric titration , hepes , piperazine , protonation , stability constants of complexes , glutathione , titration , inorganic chemistry , zinc , ternary operation , ligand (biochemistry) , medicinal chemistry , cadmium , nuclear chemistry , organic chemistry , ion , receptor , biochemistry , enzyme , computer science , programming language
The interaction of zinc(II), lead(II), and cadmium(II) with Glutathione (S‐L‐glutamyl‐Lcysteinylglycine) as primary ligand and zwitterionic buffers (N‐[2‐Hydroxyethyl]piperazine‐N′‐[2‐ethanesulfonic acid]) (HEPES) and (N‐Hydroxyethyl]piperazine‐N′‐[2‐hydroxy‐propanesulfonic acid]) (HEPPSO) as secondary ligands were studied by potentiometric‐pH titration in 1:1:1 ratio at 25.0 °C and I = 0.1 mol.dm −3 (KNO 3 ). The formation constants of different normal and protonated binary and ternary complex species were calculated. Formation constants for the monohydroxy, and dihydroxy complexes for the binary systems M(II) + HEPES and M(II) + HEPPSO have been evaluated. The distribution curves for the various complex species as a function of pH were constructed.