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Facile One Pot Microwave Assisted Solvent‐Free Synthesis of Novel Spiro‐Fused Pyran Derivatives via the Three‐Component Condensation of Ninhydrin with Malononitrile and Active Methylene Compounds
Author(s) -
Shaker Raafat M.,
Mahmoud Alaa F.,
AbdelLatif Fathy F.
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500083
Subject(s) - malononitrile , chemistry , ninhydrin , pyran , methylene , reagent , solvent , piperidine , organic chemistry , knoevenagel condensation , condensation , combinatorial chemistry , biochemistry , physics , amino acid , thermodynamics , catalysis
Three‐component condensation of ninhydrin, malononitrile, and some nucleophilic reagents in the presence of piperidine under microwave irradiation without solvent afforded the corresponding spiro‐fused pyran derivatives. The structures of the products were proved by elemental analyses, IR, 1 H NMR and MS spectroscopy.