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A Rapid and Convenient Synthesis of Derivatives of Imidazoles under Microwave Irradiation
Author(s) -
Zhao Na,
Wang YuLu,
Wang JinYe
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500078
Subject(s) - chemistry , benzil , ammonium acetate , microwave irradiation , condensation , acetic acid , aldehyde , catalysis , condensation reaction , organic chemistry , benzimidazole , high performance liquid chromatography , physics , thermodynamics
Abstract An efficient and a quick microwave‐assisted synthesis of benzimidazoles and trisubstituted imidazoles was developed. Three benzimidazoles were obtained as a result of the condensation of 1,2‐phenylenediamine with carboxylic acids and acetoacetic ester without catalyst. A series of trisubstituted imidazoles were synthesized by condensation of benzil, aromatic aldehyde and ammonium acetate in the presence of glacial acetic acid.