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Titanyl Acetylacetonate as an Efficient Catalyst for Regioselective 1,2‐Reduction of α,β‐Unsaturated Carbonyl Compounds and Conversion of α‐Diketones & Acyloins to Vicinal Diols with Sodium Borohydride
Author(s) -
Zeynizadeh Behzad
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500076
Subject(s) - chemistry , vicinal , sodium borohydride , regioselectivity , catalysis , allylic rearrangement , diketone , medicinal chemistry , organic chemistry
α,β‐Unsaturated aldehydes and ketones were reduced readily and exclusively to their corresponding allylic alcohols with NaBH 4 and catalytic amounts of titanyl acetylacetonate at room temperature. Reduction reactions were carried out in CH 3 CN or THF. This reducing system was also efficient for the reduction of α‐diketones and acyloins to their corresponding vicinal diols in CH 3 CN.