Titanyl Acetylacetonate as an Efficient Catalyst for Regioselective 1,2‐Reduction of α,β‐Unsaturated Carbonyl Compounds and Conversion of α‐Diketones & Acyloins to Vicinal Diols with Sodium Borohydride | Zendy

Zeynizadeh Behzad | Zendy

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Titanyl Acetylacetonate as an Efficient Catalyst for Regioselective 1,2‐Reduction of α,β‐Unsaturated Carbonyl Compounds and Conversion of α‐Diketones & Acyloins to Vicinal Diols with Sodium Borohydride

Author(s) -

Zeynizadeh Behzad

Publication year - 2005

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200500076

Subject(s) - chemistry , vicinal , sodium borohydride , regioselectivity , catalysis , allylic rearrangement , diketone , medicinal chemistry , organic chemistry

α,β‐Unsaturated aldehydes and ketones were reduced readily and exclusively to their corresponding allylic alcohols with NaBH 4 and catalytic amounts of titanyl acetylacetonate at room temperature. Reduction reactions were carried out in CH 3 CN or THF. This reducing system was also efficient for the reduction of α‐diketones and acyloins to their corresponding vicinal diols in CH 3 CN.

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