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Size Effect of Colloidal Selenium Particles on the Inhibition of LPS‐Induced Nitric Oxide Production
Author(s) -
Chen YueHwa,
Chang HsiaoPei,
Lin ZongHong,
Wang C. R.
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500058
Subject(s) - chemistry , nitric oxide , selenium , particle size , colloid , lipopolysaccharide , colloidal particle , nanoscopic scale , chemical engineering , particle (ecology) , biophysics , oxide , nanotechnology , organic chemistry , immunology , geology , engineering , biology , materials science , oceanography
We have studied the size‐dependent inhibition capabilities of colloidal selenium (Se) particles on lipopolysaccharide (LPS)‐induced nitric oxide (NO) production in RAW 264.7 cells. Four particle sizes of the nano‐Se, ranging from 45 ˜ 220 nm in diameter, were examined. All of them, unlike their bulk material, show clear capabilities of inhibition and a trend dependent on the particles size. The inhibition becomes more potent as the particle size increases. It indicates that pursuing the reduction of colloidal sizes into nanoscale is not favoured in this biological system.