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Kinetic Spectrophotometric Determination of Famotidine in Pharmaceutical Preparations
Author(s) -
Walash Mohammed Ibrahim,
SharafElDin Mohie Khalid,
Metwally Mohamed ElSayed,
Shabana Mostafa Reda
Publication year - 2005
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200500011
Subject(s) - famotidine , chemistry , potassium permanganate , manganate , permanganate , calibration curve , dosage form , kinetic energy , chromatography , analytical chemistry (journal) , inorganic chemistry , detection limit , thermodynamics , pharmacology , medicine , power (physics) , physics , battery (electricity) , quantum mechanics
A kinetic method for the accurate and sensitive determination of famotidine has been described. The method is based on the alkaline oxidation of famotidine with potassium permanganate at a fixed time of 10 min. The formed manganate ion is measured at 610 nm. The concentration of famotidine is calculated using the calibration equation for the fixed time method. Beer's law was obeyed in the range of 1–10 μg/mL and the R.S.D. (n = 10) was 0.47%. The method has been applied successfully to commercial tablet dosage form.