Cerebrosides from the Rhizomes of Gynura Japonica

Four new cerebrosides, gynuramides I˜IV ( 1 ‐ 4 ), together with 37 known compounds were isolated from the rhizome of Gynura japonica . The structures of cerebrosides 1 ‐ 4 were determined by chemical and spectroscopic examination to be: (2 S ,3 S ,4 R ,8 E )‐2‐[( R )‐2‐hydroxypentacosanoylamino]‐8‐en‐1,3,4‐octadecanetriol, (2 S ,3 S ,4 R ,8 E )‐2‐[( R )‐2‐hydroxytetracosanoylamino]‐8‐en‐1,3,4‐octadecanetriol, (2S,3S,4R,8E)‐2‐[(R)‐2‐ hydroxytricosanoylamino]‐8‐en‐1,3,4‐octadecanetriol, and (2 S ,3 S ,4 R ,8 E )‐2‐[( R )‐2‐hydroxydocosanoylamino]‐8‐en‐1,3,4‐octadecanetriol.