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Synthesis of New Furo[2,3‐d]pyrimidines and Pyrimido[4′,5′:4,5]furo[2,3‐d]pyrimidines
Author(s) -
Moneam Maisa I. Abdel,
Geies Ahmed A.,
ElNaggar Galal M.,
Mousa Soliman M.
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400198
Subject(s) - chemistry , sodium ethoxide , alkylation , reagent , ethanol , sodium , sodium salt , medicinal chemistry , ring (chemistry) , organic chemistry , catalysis , inorganic chemistry
Sodium salt of 4‐hydroxy‐6‐methyl‐2‐phenylpyrimidine‐5‐carbonitrile ( 3 ) was subjected to alkylation with different a‐halo compounds, where the corresponding O‐alkylated products 4 a‐g were obtained. Ring closure of the O‐alkylated product 4 a‐c performed using sodium ethoxide in refluxing ethanol afforded furo[2,3‐d]pyrimidines 5 a‐c The latter compounds on reaction with a variety of reagents gave other new furopyrimidines as well as a number of furodipyrimidines.
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