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Ultrasonic Irradiated Synthesis of N ‐(5‐aryl‐2‐furoyl)thiourea Derivatives Containing Substituted Pyrimidine Ring under Phase Transfer Catalysis
Author(s) -
Xue SiJia,
Ke ShaoYong,
Wei TaiBao,
Duan LiPing,
Guo YanLing
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400151
Subject(s) - thiourea , chemistry , yield (engineering) , pyrimidine , catalysis , aryl , ring (chemistry) , nuclear chemistry , phase transfer catalyst , proton nmr , peg ratio , medicinal chemistry , organic chemistry , stereochemistry , materials science , alkyl , finance , economics , metallurgy
A series of N ‐(5‐aryl‐2‐furoyl)thiourea derivatives containing substituted pyrimidine ring were synthesized in good yield using PEG‐400 as solid‐liquid phase transfer catalyst under ultrasonic irradiation. The structures of all newly synthesized compounds were elucidated and confirmed by IR, 1 H NMR and elemental analysis. Our method has the advantage of shorter reaction time and higher reaction yield compared to the conventional heating method. Preliminary biological tests show that some of the target compounds have better inhibitory activities against roots and stalks of monocotyledon and dicotyledon plants.