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Novel Synthesis and Antibacterial Activity of Some Pyridazine Derivatives
Author(s) -
Mohamed M. I.,
Zaky H. T.,
Kandile N. G.
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400143
Subject(s) - chemistry , antibacterial activity , bacillus subtilis , staphylococcus aureus , pseudomonas aeruginosa , agar diffusion test , bacteria , proton nmr , microbiology and biotechnology , escherichia coli , stereochemistry , biochemistry , genetics , biology , gene
Various pyridazin‐3(2H)‐ones, 3‐chloropyridazines and pyridazin‐3(2H)‐thiones were synthesized and treated with the sulpha drug (knowing by sulphamethoxazole). All the new compounds were evaluated for their antibacterial activity. They showed significant antibacterial activity against Staphylococcus aureus and Bacillus subtilis (Gram + ve) and E. coli, Pseudomonas aeruginosa and Yersinia enterocolitica (Gram ‐ ve) bacteria by agar plate diffusion method. All proposed structures were confirmed by IR, 1 H NMR, Mass spectra and Elemental analysis.