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Flavonol Glycosides and Cytotoxic Triterpenoids from Alphitonia Philippinensis
Author(s) -
Jou ShengJye,
Chen ChungHsiung,
Guh JihHwa,
Lee ChunNan,
Lee ShoeiSheng
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400124
Subject(s) - chemistry , isorhamnetin , quercetin , glycoside , cytotoxicity , flavonoid , stereochemistry , cytotoxic t cell , herpes simplex virus , traditional medicine , biochemistry , in vitro , virus , antioxidant , virology , biology , kaempferol , medicine
Three new flavonol glycosides, namely, isorhamnetin 3‐ O ‐(6″‐ O ‐( Z )‐ p ‐coumaroyl)‐β‐ D ‐glucopyranoside ( 1 ), quercetin 3‐ O ‐α‐ L ‐rhamnopyranosyl(1 → 2)‐α‐ L ‐arabinopyranosyl(1 → 2)‐α‐ L ‐rhamnopyranoside ( 2 ), and quercetin 3‐ O ‐α‐ L ‐arabinopyranosyl(1 → 2)‐α‐ L ‐rhamnopyranoside ( 3 ), were isolated from the stems of Alphitonia philippinensis . Their structures were established by spectral analysis. In addition, NMR data were assigned for ceanothenic acid ( 11 ). Some of the isolated triterpenoids and flavonoid glycosides showed cytotoxicity against human PC‐3 cells and hepatoma HA22T cells, and inhibition of replication on herpes simplex virus type‐1.