2‐Cyanoacetamide in the Synthesis of Heterocyclic Compounds: Synthesis of New Polysubstituted Pyrazole, Pyridine and Pyrimidine Derivatives | Zendy

ElRady Eman A. | Zendy; Khalil Mohamed A. | Zendy

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2‐Cyanoacetamide in the Synthesis of Heterocyclic Compounds: Synthesis of New Polysubstituted Pyrazole, Pyridine and Pyrimidine Derivatives

Author(s) -

ElRady Eman A.,

Khalil Mohamed A.

Publication year - 2004

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200400118

Subject(s) - chemistry , cyanoacetamide , pyrazole , thiourea , pyridine , pyrimidine , hydrazine (antidepressant) , hydrate , reagent , phenylhydrazine , organic chemistry , thiazole , hydrazide , combinatorial chemistry , stereochemistry , chromatography

Phenylmethylenecyanoacetamide ( 1 ) was successfully transferred into polysubstituted pyrazole, pyridine and pyrimidine derivatives in a one‐pot reaction step. Hydrazine hydrate ( 2a,b ), cyanoacetamide ( 6a ), cyanothioacetamide ( 6b ), cyanoacetic acid hydrazide ( 6c ), thiosemicarbazide ( 10 ), urea ( 14a ), thiourea ( 14b ) and 2‐phenylenediamine ( 24 ) were selected as amine nucleophile reagents.

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