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Separation and Kinetic‐Spectrophotometric Determination of Ketoconazole from Formulations Using SDS‐Coated Al 2 O 3 and KMnO 4 in Alkaline‐SDS Micellar Medium
Author(s) -
Farhadi Khalil,
Bonab Hossein Sheikhloei
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400113
Subject(s) - chemistry , chromatography , extraction (chemistry) , shampoo , analytical chemistry (journal) , organic chemistry
A kinetic method for the accurate and sensitive determination of Ketoconazole (KC) has been described. The method is based on the alkaline oxidation of KC with KMnO 4 in micellar SDS medium. At a fixed time of 8 min, the formed manganate ion is spectrophotometrically measured at 610 nm. The determination of KC by the fixed‐concentration and rate constant methods is feasible with the calibration equation obtained, but the fixed time method proves to be more applicable. The proposed method was successfully used for the quantitative determination of KC in formulations after the complete separation of KC using SDS‐coated Al 2 O 3 as a suitable solid‐phase extraction system in comparison to liquid‐liquid extraction using poisonous organic solvents. Beer's law was obeyed from 0.4 to 28 μg mL −1 and the RSD% values for tablet, cream and shampoo samples were 1.8, 1.4 and 2.3, respectively. The results obtained agreed with those obtained by the USP method.