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New Approach to N ‐substituted‐1,2,3,6‐tetrahydro‐pyridine‐4‐carbaldehyde, a Precursor for Synthesizing Aricept ® , Isoguvacine, and Deethylibophyllidine
Author(s) -
Tsai MinRuei,
Sun PeiPei,
Chang MengYang,
Changa NeinChen
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400092
Subject(s) - chemistry , pyridine , combinatorial chemistry , organic chemistry , stereochemistry
A new route towards the synthesis of N ‐substituted‐4‐formylpiperidine using N ‐benzyl or tryptaminyl‐sulfonylacetamide and α,β‐unsaturated ester as starting materials is described. Formal synthesis of Aricept ® , deethylibophyllidine, and isoguvacine, which have potential biological activities, were synthesized via this strategy.