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A New Kinetic‐Photometric Method for Determination of Carbimazole
Author(s) -
Barzegar Mohsen,
Rahmani Abdolvahed,
Jabbari Ali,
Mousavi Mir Fazlollah
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400056
Subject(s) - chemistry , carbimazole , hypophosphite , linear range , detection limit , calibration curve , chromatography , kinetic energy , ionic strength , analytical chemistry (journal) , inorganic chemistry , aqueous solution , medicine , physics , disease , pathology , quantum mechanics , graves' disease
A new kinetic photometric method for determination of carbimazole (CBZ) is described. The proposed method is simple, rapid, inexpensive and sensitive for the determination of CBZ in pure and tablet forms. This method is based on the inhibitory effect of carbimazole on the palladium(II)‐catalyzed reaction between neutral red (NR) and hypophosphite (HP) ions. The effect of various parameters such as dye, hypophosphite, and Pd(II) concentrations, pH, ionic strength, and temperature were optimized. The calibration graph was linear in the range 0.04–0.30 ppm (n = 9, r = 0.9972) and the detection limit was 0.02 ppm. The relative standard deviation of the developed method was 0.70% (n = 10). The proposed method was applied for the determination of carbimazole in pure and tablet forms.