New Regioselective Synthesis and Biological Activity of Substituted 1H‐[1,2,4]Triazolo[3,4‐c][1,2,4]Triazoles | Zendy

Shawali A. S. | Zendy; Abdallah M. A. | Zendy; Abbas I. M. | Zendy; Eid G. M. | Zendy

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New Regioselective Synthesis and Biological Activity of Substituted 1H‐[1,2,4]Triazolo[3,4‐c][1,2,4]Triazoles

Author(s) -

Shawali A. S.,

Abdallah M. A.,

Abbas I. M.,

Eid G. M.

Publication year - 2004

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200400054

Subject(s) - chemistry , regioselectivity , halide , base (topology) , combinatorial chemistry , triazole , stereochemistry , medicinal chemistry , catalysis , organic chemistry , mathematical analysis , mathematics

Two regioselective synthetic approaches for the title compounds 7 via reaction of hydrazonoyl halides 1 with 3‐methylthio‐5‐phenyl‐1,2,4‐triazole 3 and base‐catalyzed cyclization of N‐phenyl‐N‐(5‐phenyl‐s‐triazol‐3‐yl)thiohydrazides 6 are described. The mechanisms of the reactions studied and the biological activity of the isolated products 6 and 7 are pointed out.

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