Synthesis of Triazoles, Oxadiazoles and Condensed Heterocyclic Compounds Containing Cinchopheny and Studies on Biological Activity of Representative Compounds

Compounds 2‐arylamino‐5‐cinchophenyl‐1,3,4‐oxadiazoline ( 7 ) and 3‐thio‐4‐amino‐5‐cinchophenyl‐1,2,4‐triazole ( 3 ) have been synthesized utilizing cinchophen as the starting material. The compound 3‐cinchopheny‐s‐triazolo[3,4‐ b ]‐1,2,3,4‐thiatriazole ( 4 ) was prepared from compound 3 . Condensation of 3 with aromatic acid in the presence of POCl 3 gave 10 new 6‐aryl‐3‐cinchopheny‐1,2,4‐triazolo[3,4‐ b ]‐1,3,4‐thiadiazoles ( 5 ). Some of the representative compounds were screened for antibacterial activity. The structures of these new compounds have been confirmed by means of elemental analysis, IR, 1 H NMR and MS.