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Synthesis of Triazoles, Oxadiazoles and Condensed Heterocyclic Compounds Containing Cinchopheny and Studies on Biological Activity of Representative Compounds
Author(s) -
Xu PengFei,
Zhang ZhiHui,
Hui XinPing,
Zhang ZiYi,
Zheng RongLiang
Publication year - 2004
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200400049
Subject(s) - chemistry , thiadiazoles , thio , elemental analysis , triazole , organic chemistry , proton nmr , combinatorial chemistry , stereochemistry
Compounds 2‐arylamino‐5‐cinchophenyl‐1,3,4‐oxadiazoline ( 7 ) and 3‐thio‐4‐amino‐5‐cinchophenyl‐1,2,4‐triazole ( 3 ) have been synthesized utilizing cinchophen as the starting material. The compound 3‐cinchopheny‐s‐triazolo[3,4‐ b ]‐1,2,3,4‐thiatriazole ( 4 ) was prepared from compound 3 . Condensation of 3 with aromatic acid in the presence of POCl 3 gave 10 new 6‐aryl‐3‐cinchopheny‐1,2,4‐triazolo[3,4‐ b ]‐1,3,4‐thiadiazoles ( 5 ). Some of the representative compounds were screened for antibacterial activity. The structures of these new compounds have been confirmed by means of elemental analysis, IR, 1 H NMR and MS.