Potent Antipsoriatic Agents: A Facile Preparation of Acylated Derivatives from Dithranol in a Mild Basic Reaction | Zendy

Liang David WoeiMing | Zendy; Du ChunJian | Zendy

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Potent Antipsoriatic Agents: A Facile Preparation of Acylated Derivatives from Dithranol in a Mild Basic Reaction

Author(s) -

Liang David WoeiMing,

Du ChunJian

Publication year - 2004

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200400018

Subject(s) - chemistry , dithranol , acylation , yield (engineering) , chloride , organic chemistry , acyl chloride , acetyl chloride , dermatology , psoriasis , catalysis , medicine , materials science , metallurgy

Treatment of dithranol 1 with various equivalents of acetyl chloride and Et 3 N in THF at room temperature afforded the corresponding acylated derivatives, such as 1‐acetyloxy‐ and 1,8‐diacetyloxy‐9(10 H )‐anthracenones, 6a , and 6b , as well as 1,8,9‐triacetyloxyanthracene 7a , and 1,8,9‐triacetyloxy‐10‐acetylanthracene 7b . 1,8‐Bis(trimethylacetyloxy)‐9(10 H )‐anthracenone 6c was also obtained in high yield by using pivaloyl chloride during the mild acylation.

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