Premium
The Efficient Synthesis of the Optically Active β‐Hydroxyl‐γ‐Butyrolactone Derivatives
Author(s) -
Wang Jin Xin,
Li Ying,
Zhang Chao Xin
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300168
Subject(s) - chemistry , optically active , sharpless asymmetric dihydroxylation , dihydroxylation , chiral lewis acid , lewis acids and bases , enantioselective synthesis , stereochemistry , cleavage (geology) , combinatorial chemistry , lactone , organic chemistry , catalysis , geotechnical engineering , fracture (geology) , engineering
The optically active β‐hydroxyl‐γ‐butyrolactones were synthesized from nonchiral starting material by employing reductive cleavage reaction, sharpless asymmetric epoxidation and dihydroxylation, and Lewis acid‐catalysed cyclization as key steps. This strategy can be used to prepare many chiral β‐hydroxyl‐γ‐butyrolactone analogues.