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Solid Phase Synthesis of 3‐Toluenesulfonylglutarimides
Author(s) -
Chang MengYang,
Lin KuoGing,
Chen ShuiTein,
Chang NeinChen
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300111
Subject(s) - chemistry , solid phase synthesis , amide , phase (matter) , group (periodic table) , combinatorial chemistry , organic chemistry , biochemistry , peptide
A novel route for the synthesis of 3‐toluenesulfonylglutarimides on a solid support is described. The cyclization step involves stepwise [3+3] strategy of Rink Amide resin bound onto an α‐toluenesulfonyl group with various α,β‐unsaturated esters.