New Dolabellanes from the Taiwanese Soft Coral  Clavularia Inflata | Zendy

Shen YaChing | Zendy; Pan YuLing | Zendy; Ko ChinLien | Zendy; Kuo YaoHaur | Zendy; Chen ChingYeu | Zendy

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New Dolabellanes from the Taiwanese Soft Coral Clavularia Inflata

Author(s) -

Shen YaChing,

Pan YuLing,

Ko ChinLien,

Kuo YaoHaur,

Chen ChingYeu

Publication year - 2003

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200300074

Subject(s) - chemistry , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear single quantum coherence spectroscopy , stereochemistry , coral , cytotoxicity , acetylation , acetone , bioassay , fractionation , epidermoid carcinoma , organic chemistry , biochemistry , carcinoma , in vitro , medicine , biology , gene , art , genetics , visual arts

Bioassay‐directed fractionation of the acetone extract of Clavularia inflata collected in Green Island has afforded two new dolabellane diterpenoids, designated as clavinflols A ( 4 ) and B ( 5 ) in addition to the reported (1 R *,12 R *)‐dolabella‐4(16),7,10‐triene‐3,13‐dione ( 1 ), stolonidiol ( 2 ) and stolonidiol monoacetate ( 3 ). The structures of compounds 4 and 5 were determined on the basis of 1D and 2D‐NMR techniques including COSY, HSQC, HMBC and NOESY experiments, and acetylation which yielded derivatives 6 and 7 , respectively. Pharmacological study revealed that compounds 1–3 and 5 exhibited cytotoxicity against human oral epidermoid carcinoma (KB) cells while compound 4 showed selective activity toward human Hepa cells.

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