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New Dolabellanes from the Taiwanese Soft Coral Clavularia Inflata
Author(s) -
Shen YaChing,
Pan YuLing,
Ko ChinLien,
Kuo YaoHaur,
Chen ChingYeu
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300074
Subject(s) - chemistry , two dimensional nuclear magnetic resonance spectroscopy , heteronuclear single quantum coherence spectroscopy , stereochemistry , coral , cytotoxicity , acetylation , acetone , bioassay , fractionation , epidermoid carcinoma , organic chemistry , biochemistry , carcinoma , in vitro , medicine , biology , gene , art , genetics , visual arts
Bioassay‐directed fractionation of the acetone extract of Clavularia inflata collected in Green Island has afforded two new dolabellane diterpenoids, designated as clavinflols A ( 4 ) and B ( 5 ) in addition to the reported (1 R *,12 R *)‐dolabella‐4(16),7,10‐triene‐3,13‐dione ( 1 ), stolonidiol ( 2 ) and stolonidiol monoacetate ( 3 ). The structures of compounds 4 and 5 were determined on the basis of 1D and 2D‐NMR techniques including COSY, HSQC, HMBC and NOESY experiments, and acetylation which yielded derivatives 6 and 7 , respectively. Pharmacological study revealed that compounds 1–3 and 5 exhibited cytotoxicity against human oral epidermoid carcinoma (KB) cells while compound 4 showed selective activity toward human Hepa cells.