Synthesis of Galanthamine Analogs as Acetylcholinesterase Inhibitors via Intramolecular Heck Cyclization | Zendy

Liang PiHui | Zendy; Hsin LingWei | Zendy; Pong SungLing | Zendy; Hsu ChiaHuei | Zendy; Cheng ChenYu | Zendy

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Synthesis of Galanthamine Analogs as Acetylcholinesterase Inhibitors via Intramolecular Heck Cyclization

Author(s) -

Liang PiHui,

Hsin LingWei,

Pong SungLing,

Hsu ChiaHuei,

Cheng ChenYu

Publication year - 2003

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200300071

Subject(s) - chemistry , benzamide , benzazepine , intramolecular force , heck reaction , stereochemistry , acetylcholinesterase , ring (chemistry) , medicinal chemistry , catalysis , organic chemistry , enzyme , palladium

A novel approach towards the construction of the galanthamine skeleton was demonstrated by the Pd‐catalyzed cyclization of N ‐[2‐(1,4‐dioxa‐spiro[4,5]dec‐7‐en‐8‐yl)‐ethyl]‐2‐iodo‐4‐methoxy‐ N ‐methyl‐benzamide ( 23 ), with formation of the benzazepine ring and creation of a quaternary carbon.

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