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Estimation of the Taurocholate to Lecithin Molar Ratio of Mixed Micelles in Taurocholate‐Lecithin Solutions by an Interaction Model and Laser Light‐Scattering Measurements
Author(s) -
Liu ChenLun,
Weng MingShin
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300053
Subject(s) - chemistry , micelle , lecithin , chromatography , analytical chemistry (journal) , hydrodynamic radius , molar ratio , dynamic light scattering , molar mass , aqueous solution , chemical engineering , organic chemistry , nanoparticle , polymer , catalysis , engineering
The taurocholate (TC) to lecithin (L) molar ratio (K) and molecular weight of mixed TC‐L micelles coexisting with simple TC micelles were determined by employing laser light‐scattering measurement and an interaction model of mixed and simple micelles. When the nonmixed micellar taurocholate (NMTC) concentration was greater than 25 mM, the K value and molecular weight of mixed TC‐L micelles were ∼ 4.3 and ∼ 20,000 daltons, respectively, at an L concentration of 6 mM, and ∼ 2.0 and ∼ 35,000 daltons at L concentrations of 12 mM and 21 mM. A quantitative model of the formation of simple TC micelles and mixed TC‐L micelles indicated that, when the NMTC concentration was greater than 25 mM, mixed TC‐L micelles were unstable at low L levels because of low concentrations of L monomers.