Premium
A Carbazole Derivative Synthesis for Stabilizing the Quadruplex Structure
Author(s) -
Chang ChengChung,
Wu JinYi,
Chang TaChau
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300026
Subject(s) - chemistry , carbazole , g quadruplex , fluorescence , melting temperature , molecule , derivative (finance) , sequence (biology) , dna , in vitro , telomere , iodine , stereochemistry , photochemistry , organic chemistry , biochemistry , physics , materials science , quantum mechanics , financial economics , economics , composite material
A new molecule of 3,6‐Bis(1‐methyl‐4‐vinylpyridium iodine)carbazole ( BMVC ) was synthesized for stabilizing the quadruplex structure of human telomeric sequence of d(T 2 AG 3 ) 4 in vitro . Mixing BMVC with the DNA can raise the melting temperature of the d(T 2 AG 3 ) 4 by ∼ 13 °C, implying that BMVC could be a useful telomerase inhibitor. In addition, the fluorescence of the BMVC increased significantly upon interacting with the d(T 2 AG 3 ) 4 which may be useful as a G‐quadruplex specific marker.