Bromelain Catalyzed Synthesis of Peptides in Organic Solvent | Zendy

Tai DarFu | Zendy; Fu ShuLin | Zendy

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Bromelain Catalyzed Synthesis of Peptides in Organic Solvent

Author(s) -

Tai DarFu,

Fu ShuLin

Publication year - 2003

Publication title -

journal of the chinese chemical society

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.329

H-Index - 45

eISSN - 2192-6549

pISSN - 0009-4536

DOI - 10.1002/jccs.200300025

Subject(s) - chemistry , aspartame , bromelain , catalysis , organic solvent , yield (engineering) , solvent , combinatorial chemistry , organic chemistry , peptide , dipeptide , organic synthesis , enzyme , biochemistry , chemical engineering , materials science , engineering , metallurgy , protease

For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz‐Gly‐ l ‐Leu‐OMe in 85% yield. The precursor of aspartame (Cbz‐ l ‐Asp‐ l ‐Phe‐OMe) and other dipeptides were also synthesized by this method.

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