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Bromelain Catalyzed Synthesis of Peptides in Organic Solvent
Author(s) -
Tai DarFu,
Fu ShuLin
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300025
Subject(s) - chemistry , aspartame , bromelain , catalysis , organic solvent , yield (engineering) , solvent , combinatorial chemistry , organic chemistry , peptide , dipeptide , organic synthesis , enzyme , biochemistry , chemical engineering , materials science , engineering , metallurgy , protease
For the first time, immobilized bromelain was shown to maintain high catalytic activity in organic solvent and to form peptide bonds. It requires only 7 hours to obtain Cbz‐Gly‐ l ‐Leu‐OMe in 85% yield. The precursor of aspartame (Cbz‐ l ‐Asp‐ l ‐Phe‐OMe) and other dipeptides were also synthesized by this method.