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Cytotoxic and Antiplatelet Aggregation Principles of Ruta Graveolens
Author(s) -
Wu TianShung,
Shi LiShian,
Wang JhiJoung,
Iou SongChou,
Chang HsienChang,
Chen YuhPan,
Kuo YaoHaur,
Chang YaLing,
Tenge CheMing
Publication year - 2003
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200300024
Subject(s) - chemistry , cytotoxic t cell , hela , psoralen , arachidonic acid , platelet aggregation , traditional medicine , cytotoxicity , stereochemistry , biochemistry , platelet , cell , in vitro , immunology , enzyme , medicine , dna , biology
Nineteen compounds have been isolated from the methanol extract of the root and aerial parts of Ruta graveolens . The structural elucidation of these isolated compounds were determined by the spectroscopic methods and/or comparison of the physical data with literature values. Their antiplatelet aggregation and cytotoxic activities were examined to find potent antiplatelet aggregation and cytotoxic compounds from natural resources. Among them, dictamine ( 5 ), skimmianine ( 7 ), psoralen ( 8 ), chalepensin ( 12 ), clausindin ( 13 ), and graveolinine ( 16 ) showed significant inhibition of platelet aggregation, induced by arachidonic acid and collagen. Arborinine ( 2 ), dictamine ( 5 ), isopimpinellin ( 11 ), clausindin ( 13 ), and graveoline ( 17 ) exhibited cytotoxic activity against KB, Hela, DLD, NCI and Hepa tumor cell lines.