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Cyclization Reactions of 5‐Aminopyrazoles with β‐Ketoesters, Enamines and β‐Keto Anilides: New Synthetic Routes to Pyrazolo[1,5‐a]Pyrimidine Derivatives
Author(s) -
ElTaweel F. M. A.,
Elmaati T. M. Abu
Publication year - 2002
Publication title -
journal of the chinese chemical society
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.329
H-Index - 45
eISSN - 2192-6549
pISSN - 0009-4536
DOI - 10.1002/jccs.200200151
Subject(s) - chemistry , pyrimidine , medicinal chemistry , combinatorial chemistry , organic chemistry , stereochemistry
The pyrazolo[1,5‐a]pyrimidines 4, 10, 11 and 14 were synthesized from reaction of 4‐aryazo‐2,5‐diaminopyrazoles 1 with cyclic β‐ketoesters 2a,b or cyclic β‐ketoesters 7, 8 or acetoacetanilide 12 , respectively. The reaction of 1 with the enamines 15, 16 and 17 yielded also the pyrazolo[1,5‐a]pyrimidines 18, 20 and 21 , respectively.
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